Pulmonary Organoids
Recent advances in isolating epithelial progenitor cells and stromal cells, as well as defining niche factors important for lung development, have led to the establishment of an in vitro 3D lung culture system: pulmonary (lung) organoids.
Below is a collection of resources to support your pulmonary research.
Featured
Organoids: Experts Talk Standardization at Nature Research Round Table
Global organoid experts gathered in London, UK to discuss the current state of the technology, protocol standardization, translation into patient care, nomenclature, and understanding what questions a given organoid culture can and can't answer.
Read Now >Key Applications of Pulmonary Organoids
Lung Stem Cell Biology
Alder JK et al. (2015) Proc Natl Acad Sci U S A 112(16): 5099鈥104.
Barkauskas CE et al. (2013) J Clin Invest 123(7): 3025鈥36.
Frank DB et al. (2016) Cell Rep 17(9): 2312鈥25.
Gao X et al. (2015) J Cell Biol 211(3): 669鈥82.
Jain R et al. (2015) Nat Commun 6: 6727.
Hegab AE et al. (2015) Stem Cell Res 15(1): 109鈥21.
Rock JR et al. (2009) Proc Natl Acad Sci U S A 106(31): 12771鈥5.
Tadokoro T et al. (2014) Proc Natl Acad Sci U S A 111(35): E3641-9.
Tadokoro T et al. (2016) Development 143(5): 764鈥73.
Barkauskas CE et al. (2013) J Clin Invest 123(7): 3025鈥36.
Frank DB et al. (2016) Cell Rep 17(9): 2312鈥25.
Gao X et al. (2015) J Cell Biol 211(3): 669鈥82.
Jain R et al. (2015) Nat Commun 6: 6727.
Hegab AE et al. (2015) Stem Cell Res 15(1): 109鈥21.
Rock JR et al. (2009) Proc Natl Acad Sci U S A 106(31): 12771鈥5.
Tadokoro T et al. (2014) Proc Natl Acad Sci U S A 111(35): E3641-9.
Tadokoro T et al. (2016) Development 143(5): 764鈥73.
Pluripotent Stem Cell-Derived Lung Organoids
Dye BR et al. (2016) Elife 5 5: e19732.
Dye BR et al. (2015) Elife 4 4: e05098.
Gotoh S et al. (2014) Stem cell reports 3(3): 394鈥403.
Konishi S et al. (2016) Stem cell reports 6(1): 18鈥25.
Dye BR et al. (2015) Elife 4 4: e05098.
Gotoh S et al. (2014) Stem cell reports 3(3): 394鈥403.
Konishi S et al. (2016) Stem cell reports 6(1): 18鈥25.
Cancer Research and Disease Modeling
Arai D et al. (2015) J Pathol 235(4): 593鈥605.
Dai Y et al. (2016) Oncotarget. Epub ahead of print, DOI: 10.18632/oncotarget.13686.
Quantius J et al. (2016) PLoS Pathog 12(6): e1005544.
Sun L et al. (2016) Am J Cancer Res 6(10): 2277鈥88.
Dai Y et al. (2016) Oncotarget. Epub ahead of print, DOI: 10.18632/oncotarget.13686.
Quantius J et al. (2016) PLoS Pathog 12(6): e1005544.
Sun L et al. (2016) Am J Cancer Res 6(10): 2277鈥88.
Co-Culture, Extra-Cellular Matrix (ECM) and Scaffolds
Dye BR et al. (2016) Elife 5 5: e19732.
Lee J-H et al. (2014) Cell 156(3): 440鈥55.
Liang J et al. (2016) Nat Med 22(11): 1285鈥93.
Peng T et al. (2015) Nature 526(7574): 578鈥82.
Shen Y et al. (2015) Sci Rep 5: 9293.
Tan Q et al. (2017) Biomaterials 113: 118鈥32.
Lee J-H et al. (2014) Cell 156(3): 440鈥55.
Liang J et al. (2016) Nat Med 22(11): 1285鈥93.
Peng T et al. (2015) Nature 526(7574): 578鈥82.
Shen Y et al. (2015) Sci Rep 5: 9293.
Tan Q et al. (2017) Biomaterials 113: 118鈥32.
Lung Organoid Reviews
Choi J et al. (2016) Dev Biol 420(2): 278鈥86.
Dye BR et al. (2016) Curr Pathobiol Rep 4(2): 47鈥57.
Hogan BLM et al. (2014) Cell Stem Cell 15(2): 123鈥38.
Konar D et al. (2016) Biomed Eng Comput Biol 7(Suppl 1): 17鈥27.
Mou H et al. (2015) Pediatr Pulmonol (S40): S14-23.
Schilders KAA et al. (2016) Respir Res 17(1): 44.
Dye BR et al. (2016) Curr Pathobiol Rep 4(2): 47鈥57.
Hogan BLM et al. (2014) Cell Stem Cell 15(2): 123鈥38.
Konar D et al. (2016) Biomed Eng Comput Biol 7(Suppl 1): 17鈥27.
Mou H et al. (2015) Pediatr Pulmonol (S40): S14-23.
Schilders KAA et al. (2016) Respir Res 17(1): 44.
