Cardiac and Skeletal Muscle Research
Human pluripotent stem cells (hPSCs), including human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are self-renewing cells that have the potential to develop into cells of all three germ layers. hPSCs are a valuable research tool for researchers aiming to model human cardiomyocyte biology and disease. Myogenic progenitor cells, also know as satellite cells or myoblasts, have the ability to differentiate into multinucleated myotubes through myogenesis. Myoblasts can be isolated from skeletal muscle tissue for expansion and differentiation for functional studies and disease modeling.
Explore this collection of scientific resources to help you with your cardiac and skeletal muscle research.
Modeling Arrhythmias Using hPSC-Derived Cardiomyocytes and Tracking Their Excitability
In this webinar, Drs. Vincenzo Macri and Stacie Chvatal discuss their current work on tools to generate human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and to measure these cells’ excitability. These tools enable modeling of arrhythmias using patient-derived and gene-edited hPSC lines associated with genetic mutations and drug-acquired arrhythmias.
View Now >-
“Manipulating Stem Cell Fate†Featuring Dr. Shuibing ChenOn this episode of the Stem Cell Podcast, Dr. Shuibing Chen from Weill Cornell Medicine talks about using organoids to study diabetes, Zika, and SARS-CoV-2. -
How to Dissociate and Plate Human Pluripotent Stem Cell-Derived Cardiomyocytes for Microelectrode Array (MEA) AssayStep by step guide for dissociating and plating human pluripotent cell-derived cardiomyocytes for performing multiple electrode assays for studying arrhythmias -
“Development of the Heart, Lung, and Vasculature†Featuring Dr. Mingxia GuOn this episode of the Stem Cell Podcast, Dr. Mingxia Gu from Cincinnati Children’s Hospital discusses developing lung organoids to study COVID-19, how multi-lineage organoids can mimic human tissues, and her lab’s motto to “move fast and break things.†-
SnapShot: Exercise MetabolismOverview on the skeletal muscle gene expression modulation, energy sources, and inter-organ communications during exercise -
“Heart on a Chip†Featuring Dr. Christine MummeryOn this episode of the Stem Cell Podcast, Dr. Christine Mummery from the Leiden University Medical Center discusses her research developing multi-lineage cardiac model systems like microtissues and organ-chips.
