Liver Organoids
The liver is a vital organ involved in a wide range of processes such as detoxification, protein synthesis, metabolism, and hormone production. Despite an astounding regenerative capacity in vivo, expansion of liver cells in vitro has remained a challenge. Growth of the hepatic epithelium as organoids provides researchers with a stable population of liver cells for research in a variety of fields including liver biology, disease modeling and toxicity screening.
Explore the resources below for information on the expansion and maintenance of hepatic epithelial cells as organoids.
Organoids: Experts Talk Standardization at Nature Research Round Table
Global organoid experts gathered in London, UK to discuss the current state of the technology, protocol standardization, translation into patient care, nomenclature, and understanding what questions a given organoid culture can and can't answer.
Read Now >Key Applications of Hepatic Organoids
Adult Tissue-Derived Liver Organoids
Huch M, et al. (2015) Cell. 160(1-2): 299-312.
Huch M, et al. (2013) Nature. 494(7436): 247-50.
Kuijk EW, et al. (2016) Sci Rep. 6: 22154.
Nantasanti S, et al. (2015) Stem Cell Reports. 5(5): 895-907.
Disease Modeling and Cancer Research
Broutier L, et al. (2017) Nat Med. 23(12): 1424-1435.
Sampaziotis F, et al. (2015) Nat Biotechnol. 33(8): 845-852.
Hindley CJ, et al. (2016) Dev Biol. 420(2): 251-261.
Hepatic Cell Biology
Tarlow BD, et al. (2014) Hepatology. 60(1): 278-89.
Yimlamai D, et al. (2014) Cell. 157(6): 1324-38.
Kruitwagen HS, et al. (2018) Stem Cells Dev.
hPSC-Derived Liver Organoids
Takebe T, et al. (2017) Cell Rep. 21(10):2661-2670.
Takebe T, et al. (2014) Nat Protoc. 9(2): 396-409.
Organoids in Multi-Lineage Model Systems
Takebe T, et al. (2012) Transplant Proc. 44(4): 1018-20.
Skardal A, et al. (2015) Ann Biomed Eng. 43(10): 2361-73.
