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IBMX is an inhibitor of cyclic nucleotide phosphodiesterases (PDEs; IC鈧呪個 = 19, 50, 18, 13, 32, 7, and 50 碌M for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases.
DIFFERENTIATION
路 Used in combination with fibroblast growth factor (FGF) 1, dopamine, 12-O-tetradecanoylphorbol-13-acetate (TPA), and forskolin to induce expression of the dopaminergic neuron marker tyrosine hydroxylase in neurons derived from the human NT2 cell line (Iacovitti et al.).
路 Used in combination with dexamethasone, insulin, and indomethacin for in vitro induction of adipogenic differentiation of unrestricted somatic stem cells (USSCs), a CD45-negative population of stem cells isolated from human cord blood (K枚gler et al.; Pittenger et al.).
路 Induces neural differentiation from human umbilical cord blood-derived mesenchymal stem cells (MSCs; Tio et al.).
路 Promotes the differentiation of rat neural progenitor cells (NPCs) into functional neurons in vitro (Lepski et al.).
Cell Type
Adipocytes, Mesenchymal Stem and Progenitor Cells, Neural Stem and Progenitor Cells, Neurons
This product is designed for use in the following research area(s) as part
of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we
offer to support each research area.
cAMP pathway activator; Inhibits type 4 cyclic nucleotide phosphodiesterases (PDE4)
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IBMX
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