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Cell separation is an important step in countless scientific workflows, from basic research to drug development. Pre-enriching samples through isolation can help increase the proportion of desired cells, optimizing experimental outcomes. For instance, many common downstream assays, like flow cytometry and next-generation sequencing, work best when paired with pre-enriched cell populations. There are multiple methods for performing cell isolation, but your chosen method needs to be compatible with any downstream assays you plan to use.

Flow Cytometry

Analyzing the physical and chemical properties of cells is a key step in everything from basic research to clinical diagnostics. By pre-enriching samples using cell separation technology, researchers can achieve reduced sort times, greater yields, and higher purities. Read publications from scientists who have combined �������⳧���™ technology with this laser-based technology to help simplify their flow cytometry workflows:

Mass Cytometry

Scientists using this mass spectrometry technique to determine multiple properties of cells simultaneously need a reliable cell isolation method. Mass cytometry analyzes many parameters per cell, making clean and enriched samples crucial for maximizing data quality and experimental success. Explore examples of publications where �������⳧���™ has been successfully incorporated into cytometry by time of flight (CyTOF) workflows:

Next-Generation Sequencing

High-throughput approaches to DNA and RNA sequencing demand an efficient cell isolation method. Next-generation sequencing generates massive amounts of data, so starting with a focused, high-quality sample enhances accuracy, reduces cost, and improves the interpretability of results. Below are publications from scientists who have combined �������⳧���™ with massive parallel sequencing techniques:

Immune Cell Engineering

Genetic modification of immune cells to enhance their ability to recognize, target, and destroy other cells has applications in treating cancer, infections, and autoimmune diseases. Choosing a cell isolation method that delivers high purity and recovery can help to enhance target cell yield and purity, maximizing the therapeutic potential of CAR cell research. Read how researchers are using �������⳧���™ alongside gene editing, viral vectors, and synthetic biology to improve existing therapeutic options:

Proteomics and Metabolomics

In the context of cell biology, proteomics and metabolomics are powerful approaches used to analyze the functional state of cells, tissues, or organisms by profiling proteins and metabolites, respectively. Pre-enrichment via cell isolation helps to ensure that this analysis is performed on pure, well-characterized cell populations to maximize the sensitivity and specificity of results. Explore scientific papers from scientists who have incorporated �������⳧���™ into their proteomic and metabolomic analysis workflows:

In Vivo Applications

Understanding the effects of experimental manipulations on a living organism is especially important in drug discovery and pre-clinical research. Not only can heterogeneous cell populations introduce variability or undesirable effects in vivo, but unwanted cell types can dilute the therapeutic effects of treatments or cause adverse effects such as immune rejection. See how �������⳧���™-isolated cells have been incorporated into ex vivo assays and animal models by browsing the publications below:

In Vitro Assays

�������⳧���™ technology was designed to pair seamlessly with cell-based assays and organoid models, where isolating or pre-enriching cells is essential to ensure experimental precision. By working with purified cell populations, researchers can achieve more reliable data and gain deeper insights into cellular behavior and disease mechanisms. Read publications from researchers who have relied on �������⳧���™ to provide highly pure cells for their in vitro assays:

Learn more about what makes �������⳧���™ the easy choice for simplified cell isolation, view performance data, and explore the wide range of �������⳧���™ products available to isolate cells from virtually any sample source.